Heterogeneous molecular networks (including PPI, coexpression, miRNA-target binding, transcriptional regulatory networks), Alzheimer's brain scRNA-seq data, and AD-related trait data (including CERAD, Braak, CDR, cognitive function, clinical severity) are utilized to investigate and visualize the assocation of individual genes with AD.
Following the two steps below, you can obtain and visualize how the qeuried gene is associated with AD based on the various networks and AD trait data.
Note: you can input any gene of interest in the input box on the left (one gene at a time). Note that if your queried gene is a member of known AD-associated genes below, it will be removed from the list of known AD-associated genes to ensure independent evaluation.
Note: We provide three lists of AD-associated genes obtained from AlzGene, OMIM, and GWAS catalog (p-value<5E-8), respectively. You are free to make changes (add or delete) to this list. By default, the list form AlzGene is shown in the input box.